Preparation of a paeonol-containing temperature-sensitive in situ gel and its preliminary efficacy on allergic rhinitis.
In this paper, the optimal composition of Paeonol temperature-sensitive in situ gel is composed of poloxamer 407 (P407) are determined, and preliminary studies conducted its effect on allergic rhinitis. Paeonol optimum composition of the temperature-sensitive in situ gel including 2% Paeonol inclusion, 22% P407, 2% poloxamer 188 (P188) and 2% PEG6000, as assessed by the study of thermodynamic and rheological. Model frog palate was employed t o study Preparation of a phenol-containing temperature-sensitive in situ gel and its preliminary efficacy on allergic rhinitis. Cavia Clia Kits the toxicity of Paeonol temperature-sensitive in situ gel in the nasal mucosa. The results showed low toxicity to the cilia, which allows the gel to be used for nasal administration. Franz diffusion cell method is used to study the in vitro release of Paeonol and suggests that the in vitro release is in line with Higuchi equation. These results indicate that Paeonol can be absorbed int...